在基于人群的宫颈筛查中确诊的细胞学诊断的阴道加德纳菌感染和宫颈（前）肿瘤形成。
Cytologically diagnosed Gardnerella vaginalis infection and cervical (pre)neoplasia as established in population-based cervical screening.
作者信息
Klomp Johanna M, Boon Mathilde E, Van Haaften Maarten, Heintz A Peter M
机构信息
Leiden Cytology and Pathology Laboratory, Leiden, the Netherlands.
出版信息
Am J Obstet Gynecol. 2008 Nov;199(5):480.e1-5. doi: 10.1016/j.ajog.2008.04.036. Epub 2008 Jun 20.
OBJECTIVE
Cervical inflammation has been proposed as a cofactor in the development of cervical cancer. The purpose of this study was to document the prevalence of cervical (pre)neoplastic changes in asymptomatic women with a cytologically diagnosed Gardnerella vaginalis infection.
STUDY DESIGN
Data were collected from 800,498 Dutch asymptomatic women, participating in the Dutch national screening program. Prevalences of (pre)neoplasia were calculated for G vaginalis smears using a healthy flora as reference.
RESULTS
The prevalence of G vaginalis infection was 0.6 per thousand. The odds ratio for (pre)neoplasia was significantly higher in smears with G vaginalis infection compared with smears of women with a healthy vaginal flora (odds ratio, 10.3; 95% confidence interval, 6.6-16.1).
CONCLUSION
Cytologically diagnosed G vaginalis smears show a strong covariation with the presence of cervical (pre)neoplasia. Future research should therefore focus on the exact causal relation between cytologic G vaginalis infection and the presence of (pre)neoplastic changes of the cervix.
目的
宫颈炎症被认为是宫颈癌发生的一个辅助因素。本研究的目的是记录细胞学诊断为阴道加德纳菌感染的无症状女性宫颈（癌前）病变的患病率。
研究设计
数据收集自参与荷兰国家筛查项目的800498名荷兰无症状女性。以健康菌群为参照，计算阴道加德纳菌涂片的（癌前）病变患病率。
结果
阴道加德纳菌感染的患病率为千分之0.6。与阴道菌群健康女性的涂片相比，阴道加德纳菌感染涂片的（癌前）病变优势比显著更高（优势比为10.3；95%置信区间为6.6-16.1）。
结论
细胞学诊断的阴道加德纳菌涂片与宫颈（癌前）病变的存在密切相关。因此，未来的研究应聚焦于细胞学诊断的阴道加德纳菌感染与宫颈（癌前）病变存在之间的确切因果关系。
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