Yalcin Ipek, Belzung Catherine, Surget Alexandre
Université François Rabelais de Tours, France.
Behav Brain Res. 2008 Nov 3;193(1):140-3. doi: 10.1016/j.bbr.2008.04.021. Epub 2008 May 2.
There have been few comparisons of strains and antidepressants in the unpredictable chronic mild stress (UCMS) paradigm in mice. This study was undertaken to determine the influence of such factors using four antidepressants drugs including the tricyclics imipramine (20 mg/(kgday)) and desipramine (10 mg/(kgday)), the tetracyclic maprotiline (20 mg/(kgday)) and the selective serotonin reuptake inhibitor (SSRI) fluoxetine (10mg/(kgday)) in both Swiss and BALB/c mice. A 6-week UCMS regimen induced deterioration of the coat state and decreased grooming behaviours in the splash test in BALB/c mice but not Swiss mice. The four antidepressants reversed the UCMS-induced effects in BALB/c mice in both measures. However, imipramine and fluoxetine reached significance in the splash test while desipramine and maprotiline displayed only a trend. In conclusion, these results emphasize that BALB/c mice are more sensitive than Swiss mice for studying the effects of the UCMS model as well as for testing antidepressant-like properties.
在小鼠不可预测的慢性轻度应激（UCMS）模型中，很少有关于不同品系小鼠与抗抑郁药物的比较研究。本研究旨在使用四种抗抑郁药物，包括三环类药物丙咪嗪（20毫克/（千克·天））和地昔帕明（10毫克/（千克·天））、四环类药物马普替林（20毫克/（千克·天））以及选择性5-羟色胺再摄取抑制剂（SSRI）氟西汀（10毫克/（千克·天）），来确定这些因素对瑞士小鼠和BALB/c小鼠的影响。为期6周的UCMS方案导致BALB/c小鼠被毛状态变差，在甩尾试验中的理毛行为减少，但对瑞士小鼠没有影响。四种抗抑郁药物均可逆转UCMS对BALB/c小鼠这两项指标的影响。然而，丙咪嗪和氟西汀在甩尾试验中达到显著水平，而地昔帕明和马普替林仅显示出一定趋势。总之，这些结果强调，在研究UCMS模型的效应以及测试类抗抑郁特性方面，BALB/c小鼠比瑞士小鼠更敏感。
