Sarkisova K Iu, Folomkina A A
Zh Vyssh Nerv Deiat Im I P Pavlova. 2010 Jan-Feb;60(1):98-108.
A possibility to correct behavioral symptoms of depression-like behasior in WAG/Rij rats with selective serotonin reuptake inhibitor antidepressant drug fluoxetine was studied. The efficacy of fluoxetine was compared with that of tricyclic antidepressant imipramine. Vehicle-treated WAG/Rij rats compared with the corresponding group of Wistar rats exhibited symptoms of depression-like behavior: a decreased level of exploratory activity and grooming reactions in the open field test, increased immobility in the forced swimming test, and decreased sucrose intake and preference (anhedonia). Differences in anxiety level in the light-dark choice test between WAG/Rij and Wistar rats were not found. Chronic injection of fluoxetine (5 mg/kg, i.p., for 15 days) didn't exert substantial influence on the anxiety level in the light-dark choice test both in WAG/Rij and Wistar rats. In the open field test, fluoxetine didn't significantly affect behavior of "depressive" WAG/Rij rats but induced anxiogenic effect in "normal" Wistar rats (a decrease in the number of center entries and an increase in the number of grooming reactions). In the forced swimming test, fluoxetine induced antidepressant effect (a decrease in immobility time and increase in the time of swimming) statistically significant in Wistar rats and at the level of tendency in WAG/Rij rats. In the sucrose consumption test, fluoxetine enhanced sucrose intake in "depressive" WAG/Rij rats and induced a tendency to a decrease in sucrose intake in "normal" Wistar rats. Fluoxetine didn't change sucrose preference (%) both in WAG/Rij and Wistar rats. In "depressive" WAG/Rij rats, selective serotonin reuptake inhibitor antidepressant fluoxetine was less effective than tricyclic antidepressant imipramine. However, a therapeutic effect of imipramine was apparent only after the cessation of chronic treatment. During treatment, worsening ofbehavioral characteristics was seen not only in "normal" Wistar rats but to an even greater degree in "depressive" WAG/Rij rats. Fluoxetine caused worsening of some behavioral characteristics only in "normal" Wistar rats. In "depressive" WAG/Rij rats, the therapeutic effect offluoxetine developed earlier than that of imipramine and was not accompanied by an adverse side effect on behavior of animals.
研究了用选择性5-羟色胺再摄取抑制剂抗抑郁药氟西汀纠正WAG/Rij大鼠抑郁样行为的行为症状的可能性。将氟西汀的疗效与三环类抗抑郁药丙咪嗪的疗效进行了比较。与相应的Wistar大鼠组相比，给予赋形剂处理的WAG/Rij大鼠表现出抑郁样行为症状：旷场试验中探索活动水平和修饰反应降低、强迫游泳试验中不动时间增加、蔗糖摄入量和偏好降低（快感缺失）。未发现WAG/Rij大鼠和Wistar大鼠在明暗选择试验中的焦虑水平存在差异。慢性注射氟西汀（5mg/kg，腹腔注射，共15天）对WAG/Rij大鼠和Wistar大鼠在明暗选择试验中的焦虑水平均未产生实质性影响。在旷场试验中，氟西汀对“抑郁”的WAG/Rij大鼠的行为没有显著影响，但在“正常”的Wistar大鼠中诱导了致焦虑效应（中央进入次数减少和修饰反应次数增加）。在强迫游泳试验中，氟西汀在Wistar大鼠中诱导了抗抑郁效应（不动时间减少和游泳时间增加），具有统计学意义，在WAG/Rij大鼠中则有这种趋势。在蔗糖消耗试验中，氟西汀增加了“抑郁”的WAG/Rij大鼠的蔗糖摄入量，并在“正常”的Wistar大鼠中诱导了蔗糖摄入量减少的趋势。氟西汀在WAG/Rij大鼠和Wistar大鼠中均未改变蔗糖偏好（%）。在“抑郁”的WAG/Rij大鼠中，选择性5-羟色胺再摄取抑制剂抗抑郁药氟西汀的效果不如三环类抗抑郁药丙咪嗪。然而，丙咪嗪的治疗效果仅在慢性治疗停止后才明显。在治疗期间，行为特征的恶化不仅在“正常”的Wistar大鼠中出现，在“抑郁”的WAG/Rij大鼠中更为明显。氟西汀仅在“正常”的Wistar大鼠中导致一些行为特征恶化。在“抑郁”的WAG/Rij大鼠中，氟西汀的治疗效果比丙咪嗪出现得更早，且未对动物行为产生不良副作用。
