Feng Yunxia, Zhang Jianzhong, Dai Liping, Zhang Jianying, Wang Peng, Zang Jing, Li Yuchun, Wang Kaijuan
Department of Epidemiology, College of Public Health, ZhengZhou University, No. 100 Science Road, ZhengZhou 450001, China.
Cancer Lett. 2008 Nov 8;270(2):250-9. doi: 10.1016/j.canlet.2008.05.013. Epub 2008 Jun 18.
The purpose of this study was to test the associations about Helicobacter pylori infection and polymorphisms of IL-1B-31/-511 and IL-1RN VNTR polymorphism with gastric cancer in cases' and controls' family members from the areas of high cancer prevalence in China. IL-1B-511T and IL-1RN *2 were associated with risks of gastric cancer. The association strength reduced with the relative degree decreasing. Such association was not found in the polymorphisms of IL-1B-31. But the haplotype analysis of IL-1B-511 and IL-1B-31 genotype could enhance the risks of gastric cancer. The positive H. pylori status could increase the risks of IL-1B to gastric cancer.
本研究旨在检测中国癌症高发地区病例和对照家庭成员中幽门螺杆菌感染、白细胞介素-1β（IL-1B）-31/-511多态性及白细胞介素-1受体拮抗剂（IL-1RN）可变数目串联重复序列（VNTR）多态性与胃癌的相关性。IL-1B-511T和IL-1RN *2与胃癌风险相关。随着亲缘程度降低，关联强度减弱。IL-1B-31多态性未发现此类关联。但IL-1B-511和IL-1B-31基因型的单倍型分析可增加胃癌风险。幽门螺杆菌阳性状态可增加IL-1B对胃癌的风险。
