用针对NY-ESO-1的自体CD4+ T细胞治疗转移性黑色素瘤。
Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1.
作者信息
Hunder Naomi N, Wallen Herschel, Cao Jianhong, Hendricks Deborah W, Reilly John Z, Rodmyre Rebecca, Jungbluth Achim, Gnjatic Sacha, Thompson John A, Yee Cassian
机构信息
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
出版信息
N Engl J Med. 2008 Jun 19;358(25):2698-703. doi: 10.1056/NEJMoa0800251.
Abstract
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.
摘要
我们开发了一种体外方法，用于分离和扩增对黑色素瘤相关抗原NY-ESO-1具有特异性的自体CD4+ T细胞克隆。我们将这些细胞注入一名患有难治性转移性黑色素瘤的患者体内，该患者此前未接受过任何预处理或细胞因子治疗。我们发现，转移的CD4+ T细胞介导了持久的临床缓解，并引发了针对NY-ESO-1以外的黑色素瘤抗原的内源性反应。
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