Davis G J, McCloud L C, Nichols G R, Martin A W
Department of Pathology, University of Louisville School of Medicine, KY.
J Forensic Sci. 1991 May;36(3):921-5.
Pulmonary embolization of cerebral tissue as the result of severe head trauma is an uncommon, if not rare, phenomenon, and few cases have been reported in the literature. The authors discuss the case of a 51-year-old male who died six days after suffering extensive head trauma in a motor vehicle collision. At autopsy, white-gray emboli were found in several subsegmental pulmonary arteries. The results of histologic examination with the hematoxylineosin stain gave the impression that the emboli were necrotic cerebral tissue; however, routine special stains for neural tissue produced inconclusive results. Immunohistochemical staining of the emboli with monoclonal mouse anti-human neurofilament protein (Dako Corp., Carpinteria, California) confirmed the cerebral nature of the emboli. To the authors' knowledge, this is the first reported case of pulmonary embolization of cerebral tissue confirmed by immunohistochemistry.
严重头部创伤导致脑组织肺栓塞是一种即便不罕见也较为少见的现象，文献中报道的病例很少。作者讨论了一名51岁男性的病例，该男性在机动车碰撞中遭受广泛头部创伤六天后死亡。尸检时，在几条肺亚段动脉中发现了灰白色栓子。苏木精-伊红染色的组织学检查结果显示栓子为坏死的脑组织；然而，神经组织的常规特殊染色结果不明确。用单克隆小鼠抗人神经丝蛋白（Dako公司，加利福尼亚州卡平特里亚）对栓子进行免疫组织化学染色，证实了栓子的脑源性。据作者所知，这是首例经免疫组织化学证实的脑组织肺栓塞病例。
