Collins K A, Davis G J
Department of Pathology, Bowman Gray School of Medicine, Winston-Salem, North Carolina.
J Forensic Sci. 1994 May;39(3):624-8.
In an attempt to determine the incidence of pulmonary embolization of cerebral tissue as the result of severe head trauma with and without dural penetration, we have collected the autopsy reports at our institution of all head injury victims over the past 3.5 years. The retrospective and prospective histologic examination of these cases revealed a total of 10% to have emboli of cerebral tissue within the pulmonary vasculature. Immunohistochemical staining of the emboli confirmed the neural origin of the tissue. The dura mater proved to be intact in 70% of the cases of cerebral embolization. We feel this provides evidence that embolization of cerebral tissue may occur without rupture of the dura and/or large venous sinuses. This observation is of clinical as well as forensic importance, as cerebral tissue emboli are a rich source of thromboplastin in the systemic and pulmonary vasculature and may contribute to the morbidity and mortality of head injuries.
为了确定伴有或不伴有硬脑膜穿透的严重头部创伤导致脑组织肺栓塞的发生率，我们收集了本机构过去3.5年所有头部受伤受害者的尸检报告。对这些病例进行回顾性和前瞻性组织学检查发现，共有10%的病例在肺血管系统中有脑组织栓子。栓子的免疫组织化学染色证实了组织的神经起源。在70%的脑栓塞病例中，硬脑膜被证明是完整的。我们认为这提供了证据，表明脑组织栓塞可能在硬脑膜和/或大静脉窦未破裂的情况下发生。这一观察结果具有临床和法医意义，因为脑组织栓子是全身和肺血管系统中丰富的凝血活酶来源，可能导致头部损伤的发病率和死亡率。
