Fredman P, Vedeler C A, Nyland H, Aarli J A, Svennerholm L
Department of Neurochemistry, University of Göteborg, Hisings Backa, Sweden.
J Neurol. 1991 Apr;238(2):75-9. doi: 10.1007/BF00315684.
Sera from 23 patients with acute Guillain Barré syndrome (GBS), 15 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and from 40 age-matched blood donors were analysed for antibodies to acidic glycosphingolipids from human brain and peripheral nerve. Antibodies to ganglioside LM1, the major ganglioside of peripheral nerve myelin. were found in 43% of GBS and in 67% of CIDP patients' sera, and in 20% of the blood donors. However, antisulphatide antibodies were detected in 65% and 87% of the sera from GBS and CIDP patients, respectively, but only in 15% of the control sera. Sulphatide is the major acidic glycosphingolipid in myelin and its concentration in peripheral nerve myelin is 100 times higher than that of LM1. The high frequency of LM1 and, in particular of sulphatide antibodies, might thus be relevant to the pathogenesis of the GBS and CIDP.
对23例急性吉兰-巴雷综合征（GBS）患者、15例慢性炎性脱髓鞘性多发性神经根神经病（CIDP）患者以及40名年龄匹配的献血者的血清进行分析，检测其针对人脑和周围神经酸性糖鞘脂的抗体。在43%的GBS患者血清、67%的CIDP患者血清以及20%的献血者血清中发现了针对神经节苷脂LM1（周围神经髓鞘的主要神经节苷脂）的抗体。然而，分别在65%的GBS患者血清和87%的CIDP患者血清中检测到抗硫脂抗体，而在对照血清中仅15%检测到。硫脂是髓鞘中的主要酸性糖鞘脂，其在周围神经髓鞘中的浓度比LM1高100倍。因此，LM1抗体尤其是硫脂抗体的高频率出现可能与GBS和CIDP的发病机制有关。
