Leboff M S, Wade J P, Mackowiak S, el-Hajj Fuleihan G, Zangari M, Liang M H
Endocrine-Hypertension Division, Brigham and Women's Hospital, Boston, MA 02115.
J Rheumatol. 1991 Mar;18(3):339-44.
To assess whether low doses of prednisone produce generalized alterations in skeletal homeostasis in rheumatoid arthritis (RA), indices of calcium metabolism and bone mineral density (BMD) were measured in 22 women with RA treated without or with prednisone (6.6 mg daily). Ionized and total calcium concentrations, intact parathyroid hormone (PTH) and osteocalcin levels were comparable in the 2 groups. BMD measurements in the lumbar spine, and proximal femur sites including the femoral neck, Ward's triangle, and trochanteric region were not significantly different in patients with RA treated without or with prednisone. In our experience low dose prednisone did not adversely affect indices of mineral metabolism, or bone density in RA.
为评估低剂量泼尼松是否会引起类风湿关节炎（RA）患者骨骼内环境稳定的全身性改变，对22例接受或未接受泼尼松（每日6.6毫克）治疗的RA女性患者的钙代谢指标和骨密度（BMD）进行了测量。两组患者的离子钙和总钙浓度、完整甲状旁腺激素（PTH）和骨钙素水平相当。在接受或未接受泼尼松治疗的RA患者中，腰椎以及股骨近端部位（包括股骨颈、Ward三角区和转子区）的BMD测量结果无显著差异。根据我们的经验，低剂量泼尼松对RA患者的矿物质代谢指标或骨密度没有不利影响。
