Bierkens A F, Maes R M, Hendrikx J M, Erdos A F, de Vries J D, Debruyne F M
Department of Urology, Radboud University Hospital, Nijmegen, The Netherlands.
J Urol. 1991 Aug;146(2):287-9. doi: 10.1016/s0022-5347(17)37772-8.
Extracorporeal shock wave lithotripsy (ESWL&) can be painful. Of our population of patients treated with a Siemens Lithostar device 51.4% needed intravenous analgesia. A eutectic mixture of local anesthetics, a hydrophylic cream containing 25 mg. lidocaine and 25 mg. prilocaine per gm., proved to be effective for local analgesia. Therefore, we investigated its effectiveness during ESWL. With randomized, double-blind application the eutectic mixture of local anesthetics and placebo were evaluated in 83 patients according to the percentage of patients who required intravenous analgesia during ESWL. Of 40 patients treated with the eutectic mixture of local anesthetics 12 (30%) needed supplementary fentanyl citrate, compared to 23 of 43 (53%) placebo treated patients. Although there is no statistical significance (p = 0.32), the eutectic mixture of local anesthetics does decrease pain during ESWL and it should be particularly useful for patients in whom intravenous analgesia is contraindicated.
体外冲击波碎石术（ESWL）可能会引起疼痛。在我们使用西门子Lithostar设备治疗的患者群体中，51.4%的患者需要静脉镇痛。一种局部麻醉剂的共晶混合物，即每克含有25毫克利多卡因和25毫克丙胺卡因的亲水乳膏，被证明对局部镇痛有效。因此，我们研究了其在ESWL期间的有效性。通过随机、双盲应用，根据ESWL期间需要静脉镇痛的患者百分比，对83例患者评估了局部麻醉剂共晶混合物和安慰剂。在40例接受局部麻醉剂共晶混合物治疗的患者中，有12例（30%）需要补充枸橼酸芬太尼，而在43例接受安慰剂治疗的患者中有23例（53%）需要补充。虽然没有统计学意义（p = 0.32），但局部麻醉剂共晶混合物确实能减轻ESWL期间的疼痛，对静脉镇痛禁忌的患者尤其有用。
