Thakur Sheetal A, Hamilton Raymond F, Holian Andrij
Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, Missoula, Montana 59812, USA.
J Immunotoxicol. 2008 Apr;5(2):151-7. doi: 10.1080/15476910802085863.
Both immune and non-immune cells express an extensive array of scavenger receptors that bind a variety of ligands including bacterial cell-wall components and lipoproteins. Over the past several years, significant advances have been made in elucidating the role of scavenger receptors, predominantly Class A scavenger receptors SR-A I/II and MARCO, on macrophages in the binding of environmental particles such as crystalline silica and titanium dioxide. Recent evidence indicates that the binding of crystalline silica to scavenger receptors leads to apoptosis of macrophages and release of mediators (e.g., proinflammatory cytokines) contributing to lung inflammation and fibrosis. In this review, we examine the evidence for the role of SR-A I/II and MARCO in binding of the environmental particles and signaling initiated by particle-receptor interaction. Emerging concepts on the molecular details of signaling cascades by engagement of scavenger receptors by the environmental particles are also discussed.
免疫细胞和非免疫细胞均表达大量的清道夫受体，这些受体可结合多种配体，包括细菌细胞壁成分和脂蛋白。在过去几年中，在阐明清道夫受体（主要是A类清道夫受体SR-A I/II和MARCO）在巨噬细胞结合环境颗粒（如结晶二氧化硅和二氧化钛）中的作用方面取得了重大进展。最近的证据表明，结晶二氧化硅与清道夫受体的结合会导致巨噬细胞凋亡，并释放促炎细胞因子等介质，从而导致肺部炎症和纤维化。在这篇综述中，我们研究了SR-A I/II和MARCO在结合环境颗粒以及颗粒-受体相互作用引发的信号传导中所起作用的证据。还讨论了关于环境颗粒与清道夫受体结合引发信号级联反应分子细节的新观点。
