Farruggia Piero, D'Angelo Paolo, Lo Cascio Manlio, Solazzo Luigi, Montemaggi Paolo, Novara Vincenzo, Alaggio Rita, Rosolen Angelo, Caselli Desiree, Arico Maurizio
Pediatric Hematology Oncology, Ospedale dei Bambini "G. Di Cristina", Palermo, Italy.
Pediatr Hematol Oncol. 2008 Jun;25(5):431-7. doi: 10.1080/08880010802104544.
Synovial sarcoma (SS) is the most common nonrhabdomyosarcomatous soft tissue sarcoma in childhood, but the head-neck site accounts for less than 5% of cases. The authors report a 10-year-old boy with SYT-SSX1 positive left parapharyngeal SS, resistant to front-line VAIA chemotherapy, who obtained a good partial response by salvage regimen (I(3)VE + CEV + I(3)VE) and local radiotherapy, so a complete surgical resection could be performed. The complete remission was subsequently consolidated by ablative high-dose chemotherapy, followed by autologous stem cell reinfusion. The child remains in complete remission at 36 months after completion of treatment.
