Colcombet Jean, Hirt Heribert
Unité de Recherche en Génomique Végétale, INRA-CNRS-UEVE, 2 rue Gaston Crémieux, 91057 Evry Cédex, France.
Biochem J. 2008 Jul 15;413(2):217-26. doi: 10.1042/BJ20080625.
Many changes in environmental conditions and hormones are mediated by MAPK (mitogen-activated protein kinase) cascades in all eukaryotes, including plants. Studies of MAPK pathways in genetic model organisms are especially informative in revealing the molecular mechanisms by means of which MAPK cascades are controlled and modulate cellular processes. The present review highlights recent insights into MAPK-based signalling in Arabidopsis thaliana (thale cress), revealing the complexity and future challenges to understanding signal-transduction networks on a global scale.
包括植物在内的所有真核生物中,许多环境条件和激素的变化都是由丝裂原活化蛋白激酶(MAPK)级联介导的。对遗传模式生物中MAPK途径的研究,对于揭示MAPK级联如何被控制以及调节细胞过程的分子机制尤其具有启发性。本综述重点介绍了对拟南芥中基于MAPK的信号传导的最新见解,揭示了在全球范围内理解信号转导网络的复杂性和未来挑战。