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[欧洲心脏手术风险评估系统(EuroSCORE)概率模型在冠状动脉搭桥手术患者中的验证]

[Validation of the EuroSCORE probabilistic model in patients undergoing coronary bypass grafting].

作者信息

Lafuente Sarah, Trilla Antoni, Bruni Laia, González Raquel, Bertrán María J, Pomar José Luis, Asenjo Miguel A

机构信息

Servicio de Medicina Preventiva y Epidemiología, Hospital Clínic, IDIBAPS, Universidad de Barcelona, Barcelona, España.

出版信息

Rev Esp Cardiol. 2008 Jun;61(6):589-94.

Abstract

INTRODUCTION AND OBJECTIVES

EuroSCORE utilizes a probabilistic model for predicting the risk of in-hospital mortality in patients undergoing cardiac surgery. It is a useful instrument for evaluating quality of care. The model has two variants: the logistic EuroSCORE and the additive EuroSCORE. The aim of this study was to validate the EuroSCORE model in patients undergoing surgery at Hospital Clínic in Barcelona, Spain, and to compare the results obtained with the two variants.

METHODS

The study included all patients who received a coronary artery bypass graft (CABG) at Hospital Clínic in Barcelona in two consecutive years. The model's validity was assessed on the basis of its calibration (using the Hosmer-Lemeshow test) and its discrimination (using the receiver operating characteristic [ROC] curve). The two models were compared by carrying out a descriptive analysis of mortality for the whole group and for different risk groups, and by determining the models' discriminative power.

RESULTS

A total of 498 patients underwent CABG surgery and were included in the study. The Hosmer-Lemeshow test showed that the model's calibration was satisfactory (P=.32) and the area under the ROC curve was 0.83. The observed in-hospital mortality rate was 5.8%. The predicted rate was 4.2% with the logistic EuroSCORE and 3.9% with the additive EuroSCORE. Large differences were observed in high-risk patients. In these patients, the mortality predicted by the logistic variant was closer to the actual mortality.

CONCLUSIONS

EuroSCORE's validity was found to be satisfactory and the model can be used to evaluate quality of care. In high-risk patients, mortality estimated using the logistic model was closer to the actual mortality.

摘要

引言与目的

欧洲心脏手术风险评估系统(EuroSCORE)采用概率模型预测心脏手术患者的院内死亡风险。它是评估医疗质量的有用工具。该模型有两个变体:逻辑回归EuroSCORE和相加EuroSCORE。本研究的目的是在西班牙巴塞罗那临床医院接受手术的患者中验证EuroSCORE模型,并比较两种变体的结果。

方法

该研究纳入了连续两年在巴塞罗那临床医院接受冠状动脉旁路移植术(CABG)的所有患者。基于校准(使用Hosmer-Lemeshow检验)和区分度(使用受试者工作特征[ROC]曲线)评估模型的有效性。通过对整个组和不同风险组的死亡率进行描述性分析,并确定模型的区分能力,对两种模型进行比较。

结果

共有498例患者接受了CABG手术并纳入研究。Hosmer-Lemeshow检验表明模型校准良好(P = 0.32),ROC曲线下面积为0.83。观察到的院内死亡率为5.8%。逻辑回归EuroSCORE预测率为4.2%,相加EuroSCORE预测率为3.9%。在高危患者中观察到较大差异。在这些患者中,逻辑回归变体预测的死亡率更接近实际死亡率。

结论

发现EuroSCORE的有效性令人满意,该模型可用于评估医疗质量。在高危患者中,使用逻辑回归模型估计的死亡率更接近实际死亡率。

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