Kobari Y, Koto M, Tanigawa M
Drug Development Laboratories, Chugai Pharmaceutical Co. Ltd, Tokyo, Japan.
Lab Anim. 1991 Apr;25(2):110-6. doi: 10.1258/002367791781082478.
The regression of diet-induced atherosclerosis in Göttingen Miniature Swine was investigated after a 6-month induction period. At 1 month after feeding a high-cholesterol and high-fat diet, levels of beta-lipoprotein, total cholesterol, free fatty acids and phospholipid had increased rapidly and the high levels were maintained throughout the 6 month induction period. Morphological features at 6 months showed fatty streaks in the thoracic aorta and fibrous plaques in the abdominal aorta. After return to the conventional diet at 6 months, serum lipids decreased rapidly and maintained the baseline level throughout the 9 month regression period. Histopathological findings showed the regression of fatty streaks but the fibrous plaques did not regress. The present study therefore confirms the regression of fatty streaks in the aorta of Göttingen Miniature Swine by the administration of a cholesterol lowering diet.
在6个月的诱导期后，研究了 Göttingen 小型猪饮食诱导的动脉粥样硬化的消退情况。在喂食高胆固醇和高脂肪饮食1个月后，β-脂蛋白、总胆固醇、游离脂肪酸和磷脂水平迅速升高，并在整个6个月的诱导期内维持在高水平。6个月时的形态学特征显示胸主动脉有脂肪条纹，腹主动脉有纤维斑块。6个月后恢复常规饮食后，血脂迅速下降，并在整个9个月的消退期内维持在基线水平。组织病理学结果显示脂肪条纹消退，但纤维斑块未消退。因此，本研究证实了通过给予降胆固醇饮食，Göttingen 小型猪主动脉中的脂肪条纹会消退。
