Cappell Mitchell S
Division of Gastroenterology, Department of Medicine, William Beaumont Hospital, MOB 233, 3535 West Thirteen Mile Road, Royal Oak, MI 48073, USA.
Med Clin North Am. 2008 Jul;92(4):739-60, vii-viii. doi: 10.1016/j.mcna.2008.03.002.
Hepatic disorders severely affected by pregnancy include choledochal cysts that can be compressed by the gravid uterus and potentially rupture; hepatic adenomas that exhibit accelerated growth because of hyperestrogenemia during pregnancy; acute intermittent porphyria that is exacerbated by increased female sex hormones during pregnancy; splenic artery aneurysms that can rupture during pregnancy because of compression by the gravid uterus; Budd-Chiari syndrome that is promoted by hyperestrogenemia; and hepatitis E and herpes simplex hepatitis that are particularly severe during pregnancy. Hepatic disorders unique to pregnancy include intrahepatic cholestasis of pregnancy; acute fatty liver of pregnancy; preeclampsia and eclampsia; and hemolysis, elevated liver function tests, and low platelet count (HELLP) syndrome. Most disorders uniquely related to pregnancy are treated by prompt fetal delivery as soon as the fetus is sufficiently mature.
可被妊娠子宫压迫并可能破裂的胆总管囊肿；因孕期高雌激素血症而生长加速的肝腺瘤；孕期女性性激素增加会使其加重的急性间歇性卟啉病；可因妊娠子宫压迫在孕期破裂的脾动脉瘤；由高雌激素血症引发的布加综合征；以及在孕期尤为严重的戊型肝炎和单纯疱疹病毒性肝炎。妊娠特有的肝脏疾病包括妊娠肝内胆汁淤积症；妊娠急性脂肪肝；先兆子痫和子痫；以及溶血、肝酶升高和血小板减少（HELLP）综合征。大多数与妊娠独特相关的疾病，一旦胎儿足够成熟，即通过迅速分娩胎儿来治疗。
