Munoz Santiago J
Division of Hepatology, Department of Medicine, Albert Einstein Medical Center, Philadelphia, PA 19141, USA.
Med Clin North Am. 2008 Jul;92(4):813-37, viii-ix. doi: 10.1016/j.mcna.2008.03.007.
The onset of renal failure in a patient with cirrhosis or acute liver failure is alarming because it raises the possibility of the hepatorenal syndrome (HRS). Periodic surveillance of renal function is helpful in patients with severe liver disease to detect HRS early and to help correct reversible contributing factors. Once established, HRS responds relatively poorly to medical management, although recent advances have brought hope for an improved prognosis. In this article the diagnosis, pathophysiology, and management of HRS are discussed in detail, with an emphasis on recent diagnostic and therapeutic advances.
肝硬化或急性肝衰竭患者出现肾衰竭令人担忧，因为这增加了肝肾综合征（HRS）的可能性。对严重肝病患者进行定期肾功能监测有助于早期发现HRS，并有助于纠正可逆的促成因素。一旦确诊，尽管最近的进展给改善预后带来了希望，但HRS对药物治疗的反应相对较差。本文将详细讨论HRS的诊断、病理生理学和治疗，重点是最近的诊断和治疗进展。
