兔肝9000g上清液强化后对2-亚硝基-1-苯基丙烷二聚体的体外代谢

The in vitro metabolism of 2-nitroso-1-phenylpropane dimer by fortified 9000g supernatants from rabbit liver.

作者信息

Beckett A H, Jones G R

出版信息

J Pharm Pharmacol. 1977 Jun;29(6):350-4. doi: 10.1111/j.2042-7158.1977.tb11333.x.

DOI:10.1111/j.2042-7158.1977.tb11333.x

Abstract

2-Nitroso-1-phenylpropane dimer, a postulated metabolic product of amphetamine, was metabolized by fortified 9000 g supernatants from rabbit liver, mainly by oxidation on the carbon beta to the nitrogen to form a "beta-hydroxylated nitroso dimer'. The corresponding nitro compound, ketone and alcohol were also products, the latter two but not the former being cofactor dependent. The nitroso compound was not metabolically reduced under the conditions used.

摘要

2-亚硝基-1-苯基丙烷二聚体，一种推测的苯丙胺代谢产物，被兔肝经9000g超速离心后的上清液代谢，主要是在与氮相邻的β位碳原子上发生氧化反应，形成一种“β-羟基化亚硝基二聚体”。相应的硝基化合物、酮和醇也是产物，后两者（而非前者）的生成依赖于辅因子。在所使用的条件下，亚硝基化合物不会发生代谢还原。