Beckett A H, Coutts R T, Gibson G G
J Pharm Pharmacol. 1975 Sep;27(9):659-65. doi: 10.1111/j.2042-7158.1975.tb09528.x.
A study of the in vitro metabolism of dibenzylamine with fortified rabbit liver 9000 g supernatant fractions has shown that N-oxidation is the major metabolic process. Of the total amount of dibenzylamine metabolized, 90% is converted to NN-dibenzylhydroxylamine. The primary amine, benzylamine, is formed to the extent of only 6% of total substrate metabolized. The identity of the major metabolite, NN-dibenzylhydroxylamine has been established by thin-layer chromatography, gas-liquid chromatography and combined gas-liquid chromatography-mass spectrometry.
一项利用强化兔肝9000g上清液组分对二苄胺进行体外代谢的研究表明，N-氧化是主要的代谢过程。在代谢的二苄胺总量中，90%转化为N,N-二苄基羟胺。伯胺苄胺的生成量仅占代谢底物总量的6%。主要代谢产物N,N-二苄基羟胺的身份已通过薄层色谱、气液色谱以及气液色谱-质谱联用得以确定。
