由致病性人类病毒编码的RNA干扰抑制因子。

RNAi suppressors encoded by pathogenic human viruses.

作者信息

de Vries Walter, Berkhout Ben

机构信息

Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam K3-110, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

出版信息

Int J Biochem Cell Biol. 2008;40(10):2007-12. doi: 10.1016/j.biocel.2008.04.015. Epub 2008 May 16.

DOI:10.1016/j.biocel.2008.04.015

PMID:18571459

Abstract

RNA silencing or RNAi interference (RNAi) serves as an innate antiviral mechanism in plants, fungi and animals. Human viruses, like plant viruses, encode suppressor proteins or RNAs that block or modulate the RNAi pathway. This review summarizes the mechanisms by which pathogenic human viruses affect the RNAi pathway. Furthermore, some applications of the viral RNAi suppressor functions and the consequences for antiviral therapeutic strategies that are based on RNAi are discussed.

摘要

RNA沉默或RNA干扰（RNAi）是植物、真菌和动物体内一种天然的抗病毒机制。与植物病毒一样，人类病毒编码能够阻断或调节RNAi途径的抑制蛋白或RNA。本文综述了致病性人类病毒影响RNAi途径的机制。此外，还讨论了病毒RNAi抑制功能的一些应用以及基于RNAi的抗病毒治疗策略的后果。