Dias Marcos V S, Costa Cristina S, daSilva Luis L P
Center for Virus Research, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Department of Cell and Molecular Biology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Front Microbiol. 2018 Oct 10;9:2411. doi: 10.3389/fmicb.2018.02411. eCollection 2018.
Cells from all kingdoms of life can release membrane-enclosed vesicles to the extracellular milieu. These extracellular vesicles (EVs) may function as mediators of intercellular communication, allowing the transfer of biologically active molecules between cells and organisms. It has become clear that HIV particles and certain types of EVs, such as exosomes, share many similarities regarding morphology, composition, and biogenesis. This review presents a summary of the literature describing the intricate relationship between HIV and EVs biogenesis. Also, we discuss the latest progress toward understanding the mechanisms by which EVs influence HIV pathogenesis, as well as, how HIV modulates EVs composition in infected cells to facilitate viral spread.
来自所有生命王国的细胞都可以向细胞外环境释放膜包裹的囊泡。这些细胞外囊泡（EVs）可能作为细胞间通讯的介质，允许生物活性分子在细胞和生物体之间转移。很明显，HIV颗粒和某些类型的EVs，如外泌体，在形态、组成和生物发生方面有许多相似之处。这篇综述总结了描述HIV与EVs生物发生之间复杂关系的文献。此外，我们还讨论了在理解EVs影响HIV发病机制的机制方面的最新进展，以及HIV如何调节感染细胞中EVs的组成以促进病毒传播。
