Central Manchester and Manchester Childrens' Hospital NHS Trust, Manchester, UK.
J Plast Reconstr Aesthet Surg. 2009 Oct;62(10):e368-72. doi: 10.1016/j.bjps.2007.12.076. Epub 2008 Jun 24.
Treatment of giant basal cell carcinomas (GBCC) can pose several challenges. In such instances, use of routine and recommended treatments for sporadic, average size basal cell carcinomas (BCC) is suboptimal, impractical and often leads to treatment failure. Surgical excision of such large lesions results in marked intra and postoperative morbidity. While individually, photodynamic therapy, topical imiquimod and surgical excision are all established treatments for BCC, their combined use in the treatment of GBCC has not been explored. Three patients with histologically proven GBCC were sequentially treated with three cycles of metvix photodynamic therapy followed by a 6-week course of topical imiquimod. This led to a reduction in the size of these lesions which were subsequently excised.
治疗巨大基底细胞癌（GBCC）可能会带来一些挑战。在这种情况下，对于散发性、平均大小的基底细胞癌（BCC），常规和推荐的治疗方法并不理想、不切实际，而且往往导致治疗失败。对于如此大的病变进行手术切除会导致明显的围手术期发病率。虽然光动力疗法、局部咪喹莫特和手术切除单独都是 BCC 的既定治疗方法，但它们在 GBCC 治疗中的联合使用尚未得到探索。三例组织学证实的 GBCC 患者依次接受了三个周期的 metvix 光动力治疗，随后接受了 6 周的局部咪喹莫特治疗。这导致这些病变的大小减小，随后进行了切除。
