Tehranchinia Zohreh, Rahimi Hoda, Ahadi Mahsa Seyed, Ahadi Maral Seyed
Skin Research Center, Shahid Beheshti University of Medical Sciences, Sydney, Iran.
Indian J Dermatol. 2013 Jul;58(4):327. doi: 10.4103/0019-5154.113968.
Basal cell carcinoma (BCC) is the most common type of skin cancer in humans. Photodynamic therapy (PDT) is a non-invasive therapeutic modality that may be considered as a valuable treatment option for BCC. This study was designed with the aim of evaluating the efficacy of PDT in treatment of BCC and factors that may affect the response rate.
This clinical trial was conducted on 12 patients (28 BCC lesions) who were treated with aminulevulinic acid (ALA)-PDT, monthly, up to 6 sessions and the clinical response, cosmetic results, and possible side effects were evaluated.
The study was performed on 28 BCC lesions from 12 patients. Complete response was achieved in 9 (32.1%) lesions. Complete response rate was higher in younger patients (P < 0.01) and those with smaller lesions (P < 0.001). Superficial type also had significant higher response rate (P < 0.05). Patients with history of radiotherapy for the treatment of tinea capitis in childhood showed less response (P < 0.05). Cosmetic results were excellent or good in 77.5% cases. After 6 months of follow-up, none of the resolved lesions recurred.
PDT would be a good therapeutic option in treatment of BCC with acceptable efficacy and low side effects. Younger patients, superficial BCCs, and smaller lesions show better response to ALA-PDT. History of radiotherapy may be associated with a lower response rate.
基底细胞癌（BCC）是人类最常见的皮肤癌类型。光动力疗法（PDT）是一种非侵入性治疗方式，可被视为BCC的一种有价值的治疗选择。本研究旨在评估PDT治疗BCC的疗效以及可能影响缓解率的因素。
本临床试验对12例患者（28个BCC皮损）进行，采用氨基乙酰丙酸（ALA）-PDT治疗，每月1次，共6次，并评估临床反应、美容效果及可能的副作用。
对12例患者的28个BCC皮损进行了研究。9个（32.1%）皮损达到完全缓解。年轻患者（P < 0.01）和皮损较小的患者（P < 0.001）的完全缓解率更高。浅表型的缓解率也显著更高（P < 0.05）。有儿童期头癣放射治疗史的患者反应较差（P < 0.05）。77.5%的病例美容效果为优或良。随访6个月后，所有消退的皮损均未复发。
PDT是治疗BCC的一种良好治疗选择，疗效可接受且副作用低。年轻患者、浅表型BCC和较小的皮损对ALA-PDT反应更佳。放射治疗史可能与较低的缓解率相关。
