Attaoua Redha, Ait El Mkadem Samira, Radian Serban, Fica Simona, Hanzu Felicia, Albu Alice, Gheorghiu Monica, Coculescu Mihai, Grigorescu Florin
Molecular Endocrinology Laboratory, IURC, 641 Avenue du Doyen Gaston Giraud, 34093 Montpellier Cedex 5, France.
Biochem Biophys Res Commun. 2008 Aug 22;373(2):230-4. doi: 10.1016/j.bbrc.2008.06.039. Epub 2008 Jun 20.
The FTO (Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans. To understand the role of the FTO gene in polycystic ovary syndrome (PCOS) we genotyped single nucleotide polymorphism (SNP) rs1421085 (C/T) in women with PCOS (n=207) and controls (n=100) from a Central European population. The homozygous C/C genotype showed increased prevalence in PCOS patients either obese or with metabolic syndrome (MetS) compared to lean PCOS patients or controls (27.6%, 38.9%, 22.3%, and 16.3%, respectively). In logistic regression, this genotype strongly associated with MetS (P<0.0001, OR 3.2, 95% CI 1.8-5.7) and impaired fasting glucose (IFG) with P<0.0007, OR 7.7, 95% CI 2.1-28.6, independently of BMI or age, and to AUC(gluc) during OGTT (P<0.0001, alpha=0.99), indicating an influential role of the FTO gene in the glucose intolerance component of MetS.
FTO（与脂肪量和肥胖相关）基因座最近被发现与人类肥胖症和2型糖尿病（T2D）有关。为了了解FTO基因在多囊卵巢综合征（PCOS）中的作用，我们对来自中欧人群的PCOS患者（n = 207）和对照组（n = 100）的单核苷酸多态性（SNP）rs1421085（C/T）进行了基因分型。与体型偏瘦的PCOS患者或对照组相比，纯合C/C基因型在肥胖或患有代谢综合征（MetS）的PCOS患者中患病率更高（分别为27.6%、38.9%、22.3%和16.3%）。在逻辑回归分析中，该基因型与MetS（P<0.0001，OR 3.2，95%CI 1.8 - 5.7）和空腹血糖受损（IFG）显著相关（P<0.0007，OR 7.7，95%CI 2.1 - 28.6），独立于BMI或年龄，并且与口服葡萄糖耐量试验（OGTT）期间的AUC（葡萄糖）相关（P<0.0001，α = 0.99），表明FTO基因在MetS的葡萄糖不耐受成分中具有重要作用。
