PPARG基因多态性与芬兰晚发型阿尔茨海默病之间缺乏遗传关联。
Lack of genetic association between PPARG gene polymorphisms and Finnish late-onset Alzheimer's disease.
作者信息
Helisalmi Seppo, Tarvainen Timo, Vepsäläinen Saila, Koivisto Anne Mari, Hiltunen Mikko, Soininen Hilkka
机构信息
Institute of Clinical Medicine, Unit of Neurology and Brain Research Unit, Clinical Research Center, Mediteknia, Kuopio University, Kuopio, Finland.
出版信息
Neurosci Lett. 2008 Aug 22;441(2):233-6. doi: 10.1016/j.neulet.2008.06.029. Epub 2008 Jun 17.
Single nucleotide polymorphisms (SNPs) in diabetes related peroxisome proliferator-activated receptor gamma (PPARG) gene were investigated with a case-control approach. To examine the genetic association of this gene with Alzheimer's disease (AD) risk, we used the TaqMan technique to genotype eight SNP sites for PPARG gene, in 538 Finnish AD cases and 672 controls and conducted a single allele and genotypic distribution comparison as well as estimated haplotype frequencies between cases and controls. No significant differences in AD risk were found in single SNP and haplotype analyses for PPARG gene between the study groups. We conclude that PPARG gene does not play a major role in the genetic predisposition to AD in the Finnish population.
采用病例对照研究方法，对糖尿病相关的过氧化物酶体增殖物激活受体γ（PPARG）基因中的单核苷酸多态性（SNP）进行了研究。为了检验该基因与阿尔茨海默病（AD）风险的遗传关联性，我们运用TaqMan技术对538例芬兰AD病例和672例对照的PPARG基因的8个SNP位点进行基因分型，并进行了单等位基因和基因型分布比较，以及病例组与对照组之间单倍型频率的估计。在研究组之间，PPARG基因的单SNP和单倍型分析中未发现AD风险存在显著差异。我们得出结论，在芬兰人群中，PPARG基因在AD的遗传易感性中不发挥主要作用。
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