Wang S, Guan L, Luo D, Liu J, Lin H, Li X, Liu X
Shuhua Wang, Center of Health Management, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jingwuweiqi Road, Jinan 250021, Shandong, China. Tel: +86-531-68773708, Fax: +86-531-68773708; Email address:
J Nutr Health Aging. 2017;21(4):397-403. doi: 10.1007/s12603-016-0794-y.
The aim was to investigate the impact of PPARG and APOE gene single nucleotide polymorphisms (SNPs) and additional gene- gene interaction on late-onset Alzheimer's disease (LOAD) risk based on Chinese Han population.
A total of 928 participants (466 males, 462 females), with a mean age of 81.3 ± 16.4 years old, were included in the study, including 460 LOAD patients and 468 normal controls participants. Logistic regression was performed to investigate association between SNP and LOAD risk and generalized multifactor dimensionality reduction (GMDR) was used to analysis the gene-gene interaction.
Logistic regression analysis showed that LOAD risk was significantly higher in carriers of G allele of the rs405509 polymorphism than those with AA (AG+ GG versus AA, adjusted OR (95%CI) =1.54(1.20-1.89), and higher in carriers of G allele of the rs1805192 polymorphism than those with CC (CG+ GG versus CC, adjusted OR (95%CI) =1.32(1.16-2.43). We also found that there was a potential gene-gene interaction between rs405509 and rs1805192. Participants with AG or GG of rs405509 and CG or GG of rs1805192 genotype have the highest AD risk, compared to participants with AA of rs405509 and CC of rs1805192 genotype, OR (95%CI) was 2.62(1.64 -3.58), after covariates adjustment.
G allele of the rs405509 of APOE and G allele of the rs1805192 of PPAR G polymorphism were associated with increased LOAD risk, and participants with AG or GG of rs405509 and CG or GG of rs1805192 genotype have the highest AD risk.
旨在基于中国汉族人群，研究过氧化物酶体增殖物激活受体γ（PPARG）和载脂蛋白E（APOE）基因单核苷酸多态性（SNP）以及其他基因-基因相互作用对晚发型阿尔茨海默病（LOAD）风险的影响。
本研究共纳入928名参与者（男性466名，女性462名），平均年龄为81.3±16.4岁，其中包括460例LOAD患者和468名正常对照参与者。采用逻辑回归分析SNP与LOAD风险之间的关联，并使用广义多因素降维法（GMDR）分析基因-基因相互作用。
逻辑回归分析显示，rs405509多态性的G等位基因携带者患LOAD的风险显著高于AA基因型者（AG+GG与AA相比，校正比值比（95%可信区间）=1.54（1.20-1.89）），rs1805192多态性的G等位基因携带者患LOAD的风险高于CC基因型者（CG+GG与CC相比，校正比值比（95%可信区间）=1.32（1.16-2.43））。我们还发现rs405509和rs1805192之间存在潜在的基因-基因相互作用。与rs405509为AA基因型且rs1805192为CC基因型的参与者相比，rs'405509为AG或GG基因型且rs1805192为CG或GG基因型的参与者患AD的风险最高，校正协变量后，比值比（95%可信区间）为2.62（1.64-3.58）。
APOE的rs405509的G等位基因和PPAR G多态性的rs1805192的G等位基因与LOAD风险增加相关，rs405509为AG或GG基因型且rs1805192为CG或GG基因型的参与者患AD的风险最高。
