Abedi Kiasari B, Vallely P J, Corless C E, Al-Hammadi M, Klapper P E
Virology, Genomic Epidemiology Research Group, School of Translational Medicine, University of Manchester, Manchester, M13 9WL, UK.
J Clin Virol. 2008 Sep;43(1):123-5. doi: 10.1016/j.jcv.2008.05.003. Epub 2008 Jun 24.
The role of two recently identified polyomaviruses, KI and WU, in the causation of respiratory disease has not been established.
To determine the prevalence of KI and WU viruses (KIV and WUV) in 371 respiratory samples and evaluate their contribution to respiratory disease.
Specimens were screened for KIV and WUV using single, multiplex or real time PCR; co-infection with other respiratory viruses was evaluated.
Of the 371 samples analysed, 10 (2.70%) were positive for KIV and 4 (1.08%) were positive for WUV yielding an overall case prevalence of KIV and WUV infection of 3.77%. KIV and WUV were identified in patients aged<15 years (11 patients) with upper or lower respiratory tract infection and >45 years (3 patients) with upper respiratory tract infection. Co-infections were found in 5 (50%) and 3 (75%) of the KIV and WUV positive samples, respectively.
This study supports previous conclusions that KIV and WUV detection in the respiratory tract may be coincidental and reflect reactivation of latent or persistent infection with these viruses. The age distribution of KIV and WUV infection in this study mirrors that found for the other human polyomaviruses, BK and JC.
最近发现的两种多瘤病毒，KI和WU，在呼吸道疾病病因中的作用尚未明确。
确定371份呼吸道样本中KI和WU病毒（KIV和WUV）的流行率，并评估它们对呼吸道疾病的影响。
使用单重、多重或实时PCR对样本进行KIV和WUV筛查；评估与其他呼吸道病毒的共同感染情况。
在分析的371份样本中，10份（2.70%）KIV呈阳性，4份（1.08%）WUV呈阳性，KIV和WUV感染的总体病例流行率为3.77%。在年龄<15岁的上呼吸道或下呼吸道感染患者（11例）以及年龄>45岁的上呼吸道感染患者（3例）中发现了KIV和WUV。分别在5份（50%）KIV阳性样本和3份（75%）WUV阳性样本中发现了共同感染。
本研究支持先前的结论，即呼吸道中检测到KIV和WUV可能是巧合，反映了这些病毒潜伏或持续感染的重新激活。本研究中KIV和WUV感染的年龄分布与其他人类多瘤病毒BK和JC的年龄分布相似。
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