Zhang Guozhi, Liu Qian, Zeng Shaoqun, Luo Qingming
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.
Phys Med Biol. 2008 Jul 21;53(14):3697-722. doi: 10.1088/0031-9155/53/14/001. Epub 2008 Jun 23.
The voxel-based visible Chinese human (VCH) adult male phantom has offered a high-quality test bed for realistic Monte Carlo modeling in radiological dosimetry simulations. The phantom has been updated in recent effort by adding newly segmented organs, revising walled and smaller structures as well as recalibrating skeletal marrow distributions. The organ absorbed dose against external proton exposure was calculated at a voxel resolution of 2 x 2 x 2 mm(3) using the MCNPX code for incident energies from 20 MeV to 10 GeV and for six idealized irradiation geometries: anterior-posterior (AP), posterior-anterior (PA), left-lateral (LLAT), right-lateral (RLAT), rotational (ROT) and isotropic (ISO), respectively. The effective dose on the VCH phantom was derived in compliance with the evaluation scheme for the reference male proposed in the 2007 recommendations of the International Commission on Radiological Protection (ICRP). Algorithm transitions from the revised radiation and tissue weighting factors are accountable for approximately 90% and 10% of effective dose discrepancies in proton dosimetry, respectively. Results are tabulated in terms of fluence-to-dose conversion coefficients for practical use and are compared with data from other models available in the literature. Anatomical variations between various computational phantoms lead to dose discrepancies ranging from a negligible level to 100% or more at proton energies below 200 MeV, corresponding to the spatial geometric locations of individual organs within the body. Doses show better agreement at higher energies and the deviations are mostly within 20%, to which the organ volume and mass differences should be of primary responsibility. The impact of body size on dose distributions was assessed by dosimetry of a scaled-up VCH phantom that was resized in accordance with the height and total mass of the ICRP reference man. The organ dose decreases with the directionally uniform enlargement of voxels. Potential pathways to improve the VCH phantom have also been briefly addressed. This work pertains to VCH-based systematic multi-particle dose investigations and will contribute to comparative dosimetry studies of ICRP standardized voxel phantoms in the near future.
基于体素的可见中国成人男性体模(VCH)为放射剂量学模拟中的真实蒙特卡罗建模提供了一个高质量的测试平台。最近,该体模进行了更新,增加了新分割的器官,修正了有壁和较小的结构,并重新校准了骨髓分布。使用MCNPX代码,在2×2×2 mm³的体素分辨率下,计算了20 MeV至10 GeV的入射能量以及六种理想化照射几何形状(分别为前后向(AP)、后前向(PA)、左侧向(LLAT)、右侧向(RLAT)、旋转(ROT)和各向同性(ISO))下,器官对外部质子照射的吸收剂量。根据国际放射防护委员会(ICRP)2007年建议中提出的参考男性评估方案,得出了VCH体模上的有效剂量。修订后的辐射和组织权重因子的算法转换分别占质子剂量学中有效剂量差异的约90%和10%。结果以通量到剂量转换系数的形式列表以供实际使用,并与文献中其他模型的数据进行了比较。各种计算体模之间的解剖学差异导致在质子能量低于200 MeV时,剂量差异范围从可忽略不计到100%或更高,这与身体内各个器官的空间几何位置相对应。在较高能量下,剂量显示出更好的一致性,偏差大多在20%以内,其中器官体积和质量差异应是主要原因。通过对一个根据ICRP参考人的身高和总体质量进行缩放的放大VCH体模进行剂量学研究,评估了身体大小对剂量分布的影响。器官剂量随着体素在方向上均匀增大而降低。还简要讨论了改进VCH体模的潜在途径方法。这项工作属于基于VCH的系统多粒子剂量研究,将在不久的将来为ICRP标准化体素体模的比较剂量学研究做出贡献。