Baskol Mevlut, Baskol Gulden, Koçer Derya, Ozbakir Omer, Yucesoy Mehmet
Department of Gastroenterology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
J Clin Gastroenterol. 2008 Jul;42(6):687-91. doi: 10.1097/MCG.0b013e318074f91f.
BACKGROUND/GOALS: The etiology and pathogenesis of chronic inflammatory bowel diseases are still poorly understood. Oxidative stress takes place in the pathogenesis of ulcerative colitis (UC) and advanced oxidation protein products (AOPP) are accepted as a novel marker of oxidative stress. There are no data concerning whether AOPP may be used as a simple serum marker to assess the disease activity, predict severity of the disease course in UC.
In this study, we determine the importance of neutrophil activation and the role of oxidative stress in the pathogenesis of UC, by quantification of AOPP and total thiol levels as markers of oxidative protein damage, malondialdehyde levels as a marker of lipid peroxidation, and myeloperoxidase activity as a marker of neutrophil activation in patients with UC.
Serum levels of AOPP, thiol, myeloperoxidase activity, and malondialdehyde were found as increased in UC group compared with controls (P=0.004, 0.047, 0.001, and 0.001 respectively).
Our finding of increased levels of plasma AOPP levels supports the presence of oxidative stress and protein oxidation in UC and this marker may be used as a simple serum marker to assess disease activity, predict the severity of disease course, and perhaps response to therapy.
背景/目标：慢性炎症性肠病的病因和发病机制仍未完全明确。氧化应激在溃疡性结肠炎（UC）的发病机制中起作用，而晚期氧化蛋白产物（AOPP）被认为是氧化应激的一种新标志物。目前尚无关于AOPP是否可作为一种简单的血清标志物来评估UC疾病活动度、预测疾病进程严重程度的数据。
在本研究中，我们通过定量检测AOPP和总巯基水平作为氧化蛋白损伤的标志物、丙二醛水平作为脂质过氧化的标志物以及髓过氧化物酶活性作为UC患者中性粒细胞活化的标志物，来确定中性粒细胞活化的重要性以及氧化应激在UC发病机制中的作用。
与对照组相比，UC组患者血清中AOPP、巯基、髓过氧化物酶活性和丙二醛水平均升高（分别为P = 0.004、0.047、0.001和0.001）。
我们发现血浆AOPP水平升高，这支持了UC中存在氧化应激和蛋白质氧化，并且该标志物可作为一种简单的血清标志物来评估疾病活动度、预测疾病进程的严重程度，甚至可能用于预测对治疗的反应。
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