Watanabe Yuichiro, Nunokawa Ayako, Shibuya Masako, Kaneko Naoshi, Nawa Hiroyuki, Someya Toshiyuki
Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori-ichibancho, Chuo-ku, Niigata 951-8510, Japan.
Eur Arch Psychiatry Clin Neurosci. 2008 Oct;258(7):422-7. doi: 10.1007/s00406-008-0813-z. Epub 2008 Jun 20.
Interleukin 2 (IL-2) and IL-4 are pleiotropic cytokines regulating Th1/Th2 balance and have a regulatory activity in brain function. Thus these cytokines have been implicated in the pathophysiology of schizophrenia. The latest studies provided controversial results regarding the genetic associations of these cytokines. The functional polymorphisms, IL2-330T/G and IL4-590C/T, were associated with schizophrenia in a German population, although contradictory findings were also reported in a Korean population. To ascertain whether IL2 and IL4 contribute to vulnerability to schizophrenia, we conducted a moderate-scale case-control (536 patients and 510 controls) association study for seven polymorphisms in Japanese subjects. There were no significant associations of these genes with schizophrenia using either single marker or haplotype analyses. The present study suggests that IL2 and IL4 do not contribute to vulnerability to schizophrenia in the Japanese population.
白细胞介素2（IL-2）和白细胞介素4是调节Th1/Th2平衡的多效性细胞因子，对脑功能具有调节活性。因此，这些细胞因子与精神分裂症的病理生理学有关。最新研究就这些细胞因子的基因关联给出了相互矛盾的结果。功能多态性IL2-330T/G和IL4-590C/T在德国人群中与精神分裂症相关，尽管在韩国人群中也有相互矛盾的报道。为确定IL2和IL4是否会导致精神分裂症易感性，我们针对日本受试者的7种多态性进行了一项中等规模的病例对照研究（536例患者和510例对照）。无论是单标记分析还是单倍型分析，这些基因与精神分裂症均无显著关联。本研究表明，在日本人群中，IL2和IL4不会导致精神分裂症易感性。
