Watanabe Yuichiro, Muratake Tatsuyuki, Kaneko Naoshi, Nunokawa Ayako, Someya Toshiyuki
Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Asahimachi-dori 1-757, Niigata 951-8510, Japan.
Schizophr Res. 2006 May;84(1):29-35. doi: 10.1016/j.schres.2006.03.011. Epub 2006 Apr 21.
Brain-derived neurotrophic factor (BDNF) plays important roles in the survival, maintenance and growth of neurons. Several studies have indicated that BDNF is likely to be related to the pathogenesis of schizophrenia. Recent genetic analyses have revealed that BDNF gene polymorphisms are associated with schizophrenia, although contradictory negative findings have also been reported. To assess whether three BDNF gene polymorphisms (rs988748, C132T and rs6265) could be implicated in vulnerability to schizophrenia, we conducted a case-control association analysis (349 patients and 423 controls) in Japanese subjects. We found no association between these BDNF gene polymorphisms and schizophrenia using both single-marker and haplotype analyses. The results of the present study suggest that these three BDNF gene polymorphisms do not play major roles in conferring susceptibility to schizophrenia in a Japanese population. However, further studies assessing the associations between these BDNF gene polymorphisms and schizophrenia should be performed in several other ethnic populations.
脑源性神经营养因子（BDNF）在神经元的存活、维持和生长中发挥着重要作用。多项研究表明，BDNF可能与精神分裂症的发病机制有关。最近的基因分析显示，BDNF基因多态性与精神分裂症相关，尽管也有相互矛盾的阴性结果报道。为了评估BDNF基因的三个多态性位点（rs988748、C132T和rs6265）是否与精神分裂症的易感性有关，我们对日本受试者进行了病例对照关联分析（349例患者和423例对照）。通过单标记和单倍型分析，我们发现这些BDNF基因多态性与精神分裂症之间无关联。本研究结果表明，在日本人群中，这三个BDNF基因多态性在赋予精神分裂症易感性方面不发挥主要作用。然而，应在其他几个种族人群中开展进一步研究来评估这些BDNF基因多态性与精神分裂症之间的关联。
