Vernier J M, Sire M F
Tissue Cell. 1976;8(3):531-46. doi: 10.1016/0040-8166(76)90011-2.
The evolution of the liver's glycogenic content, cytochemical characterization of the glycogen and glucose-6-phosphatase activity enable us to define three successive phases up to stage 36, just before the first feed. The grade which was low up to stage 24 is then due to beta-particles of ovule origin. Then, up to stage 27, there is a storage phase: alpha-particles appear and accumulate while the enzymatic activity remains non-existent. From the stage 28 to 36 the grade is progressively increasing, the enzymatic activity appears and increases. When the phase ends the liver is able to ensure glycemic regulation and to deal with exogenous nutritional contributions.
肝脏糖原含量的演变、糖原的细胞化学特征以及葡萄糖-6-磷酸酶活性使我们能够定义直至第36阶段(即首次喂食前)的三个连续阶段。直至第24阶段一直较低的等级是由胚珠来源的β粒子导致的。然后,直至第27阶段,存在一个储存阶段:α粒子出现并积累,而酶活性仍然不存在。从第28阶段到第36阶段,等级逐渐增加,酶活性出现并增加。当这个阶段结束时,肝脏能够确保血糖调节并应对外源营养供应。