二丁酰环磷腺苷对重症肌无力神经肌肉传递的影响。

Effect of dibutyryl cyclic AMP on neuromuscular transmission in myasthenia gravis.

作者信息

Hashimoto Y, Sasaki H, Iwatsuki K

出版信息

Tohoku J Exp Med. 1976 Oct;120(2):197-8. doi: 10.1620/tjem.120.197.

DOI:10.1620/tjem.120.197

Abstract

The effect of dibutyryl 3',5'-cyclic monophosphate (D-cAMP) on the neuromuscular transmission was studied in a patient with myasthenia gravis during anesthesia. D-cAMP caused a slight increase in single twitch tension, and an initial transient decrease in tension which resulted from the trains of 2 Hz stimuli disappeared after D-cAMP. The finding of the present study suggests that D-cAMP has an anti-fatigue effect in patients with myasthenia gravis.

摘要

在麻醉期间，对一名重症肌无力患者研究了二丁酰3',5'-环磷酸腺苷（D - cAMP）对神经肌肉传递的影响。D - cAMP使单收缩张力略有增加，并且由2Hz刺激串引起的张力最初短暂下降在给予D - cAMP后消失。本研究结果表明，D - cAMP对重症肌无力患者具有抗疲劳作用。