Ricker K, Hertel G, Stodieck S
J Neurol. 1977 Nov 1;216(4):273-82. doi: 10.1007/BF00314051.
The effect of local cooling was studied in 28 patients with myastenia gravis. We stimulated the ulnar nerve with single stimuli and trains at 3/s for 2s and at 50/s for 1.5 s. The compound muscle action potential (MAP), the muscle twitch and the isometric tetanic force of the adductor pollicis were registered. 1. At 3/s stimulation the pathological decrement of the MAP decreased after slight cooling. 2. The amplitude of the single MAP was higher at lower temperature when compared to normal temperature. The same increase is however to be found in healthy subjects. 3. After slight cooling, the maximum tetanic force was higher. However, the decrement of the force was higher also, therefore ruling out a practicable application of cooling for the patient. 4. After severe cooling (18-22 degrees C) the tetanic force was much lower and in many cases a complete failure of the neuromuscular transmission occured.
对28例重症肌无力患者进行了局部冷却效果的研究。我们用单次刺激和频率为3次/秒持续2秒以及频率为50次/秒持续1.5秒的串刺激来刺激尺神经。记录了拇内收肌的复合肌肉动作电位（MAP）、肌肉抽搐和等长强直收缩力。1. 在3次/秒刺激时，轻微冷却后MAP的病理性衰减降低。2. 与正常体温相比，在较低温度下单次MAP的幅度更高。然而，在健康受试者中也发现了同样的增加。3. 轻微冷却后，最大强直收缩力更高。然而，力量的衰减也更高，因此排除了对患者应用冷却的可行性。4. 严重冷却（18 - 22摄氏度）后，强直收缩力低得多，并且在许多情况下发生了神经肌肉传递完全失败。
