Zhao Li-Qiang, Shen Jiang, You Quan-Cheng, Wu Xiao-Rong, Han Su, Li Xiao-Li, Wang Ren-Yi
Department of Occupational Medicine, West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 May;39(3):461-3.
To study the early indicators for renal damages in mercury workers and the clinical significance.
Eighty-five mercury workers were divided into 2 experimental groups: the normal & subject-under-surveillance group and the mercury-poisoning group. Sixty-five healthy adults with no mercury exposure history were assigned as the control group. Any subjects with history of renal diseases or concurrent renal diseases were excluded. The results from physical examinations and measurements of HgU, B-Cr, U-Cr, BUN, N-acetyl-beta-D-glucosaminidase (NAG), beta2-microglobulin (beta2-MG), urinary alpha1-microglobulin (alpha1-MG), and retinol-binding protein (RBP) in all the groups were analyzed.
The levels of HgU, NAG, alpha1-MG, beta2-MG, and RBP were significantly higher in the experimental groups than in the control group. The levels of NAG, beta2-MG and RBP were significantly higher in the nomal & subject-under-surveillance group than in the control group. However, there was no statistically significant difference between the levels of B-Cr and BUN in the experimental groups and those of the control group.
Long-term exposure to mercury can cause renal damages. The level of NAG, alpha1-MG, beta2-MG, and RBP can be used as sensitive indicators for detecting early renal damages caused by mercury.
研究汞作业工人肾脏损害的早期指标及其临床意义。
将85名汞作业工人分为2个试验组：正常及观察对象组和汞中毒组。选取65名无汞接触史的健康成年人作为对照组。排除有肾脏疾病史或并发肾脏疾病的任何受试者。分析所有组的体格检查结果以及尿汞（HgU）、血肌酐（B-Cr）、尿肌酐（U-Cr）、血尿素氮（BUN）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）、β2-微球蛋白（β2-MG）、尿α1-微球蛋白（α1-MG）和视黄醇结合蛋白（RBP）的测量结果。
试验组的HgU、NAG、α1-MG、β2-MG和RBP水平显著高于对照组。正常及观察对象组的NAG、β2-MG和RBP水平显著高于对照组。然而，试验组和对照组的B-Cr和BUN水平之间无统计学显著差异。
长期接触汞可导致肾脏损害。NAG、α1-MG、β2-MG和RBP水平可作为检测汞所致早期肾脏损害的敏感指标。
