Yuan Qiang, Zou Ling, Chen Qin
Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 May;39(3):496-9.
To explore the gray matter loss of Alzheimer' s disease (AD) by voxel-based morphometry (VBM).
The cerebral gray matter (GM) concentrations of 3.0T magnetic resonance (MR) images from 12 patients of Alzheimer's disease and 10 normal control subjects were compared using optimized VBM. The characteristics of GM concentration, volume and location were analyzed by statistical parametric mapping (SPM2).
There are broad areas of gray matter loss in AD. Bilateral affected structures were hippocampal cortex, amygdala, caudate nucleus, cingulate gyrus, lower temporal gyrus and somatomotor cortex. Right insula and right frontal cortex also involved. On the other hand, somatosensory cortex, cerebellum and occipital lobe were relatively intact.
Optimized VBM based on 3T MR showed more accurate and comprehensive analysis for the widespread gray matter loss of AD.
采用基于体素的形态学测量法（VBM）探讨阿尔茨海默病（AD）患者的灰质丢失情况。
运用优化的VBM比较12例阿尔茨海默病患者和10名正常对照者的3.0T磁共振（MR）图像的脑灰质（GM）浓度。通过统计参数映射（SPM2）分析GM浓度、体积和位置的特征。
AD患者存在广泛的灰质丢失区域。双侧受累结构为海马皮质、杏仁核、尾状核、扣带回、颞下回和躯体运动皮质。右侧岛叶和右侧额叶皮质也受累。另一方面，躯体感觉皮质、小脑和枕叶相对完整。
基于3T MR的优化VBM对AD广泛的灰质丢失显示出更准确和全面的分析。
