Testa Cristina, Laakso Mikko P, Sabattoli Francesca, Rossi Roberta, Beltramello Alberto, Soininen Hilkka, Frisoni Giovanni B
Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio - FBF, Brescia, Italy.
J Magn Reson Imaging. 2004 Mar;19(3):274-82. doi: 10.1002/jmri.20001.
To compare the accuracy of voxel-based morphometry (VBM) and region of interest (ROI)-based hippocampal volumetry to detect medial temporal lobe atrophy in Alzheimer's disease (AD).
A total of 27 AD patients (age 74 +/- 9 years; 22 women; Mini-Mental State Exam [MMSE] 21 +/- 4) and 25 controls (age 70 +/- 8; 16 women; MMSE 29 +/- 1) were studied. Accuracy of VBM to detect gray matter loss in those seven AD patients and 11 controls with similar ROI-based hippocampal measures and of ROI-based volumetry to detect gray matter loss in those four AD patients and five controls with similar VBM-based hippocampal measures was assessed. VBM was performed with statistical parametric mapping (SPM99).
The area under the curve was 0.96 (95% C.I., 0.92-1.00) for VBM, 0.89 (95% C.I., 0.80-0.98) for ROI-based hippocampal measures, and 0.99 (95% C.I., 0.96-1.00) for both. In subjects with similar ROI-based hippocampal measures, VBM detected atrophy in AD patients at P < 0.0001, while in subjects with similar VBM-based hippocampal measure, volumetry was not significant (P = 0.11). Both measures independently contributed to discrimination (P = 0.004 and P = 0.032) in a logistic regression model.
These results indicate that VBM is more accurate, but the combination of both methods provides the highest accuracy for detection of hippocampal atrophy in AD.
比较基于体素的形态测量法（VBM）和基于感兴趣区域（ROI）的海马体积测量法在检测阿尔茨海默病（AD）患者内侧颞叶萎缩方面的准确性。
共研究了27例AD患者（年龄74±9岁；22名女性；简易精神状态检查表[MMSE]评分为21±4）和25名对照者（年龄70±8岁；16名女性；MMSE评分为29±1）。评估了VBM在7例AD患者和11例对照者中检测灰质丢失的准确性，这些患者和对照者具有相似的基于ROI的海马测量值；同时评估了基于ROI的体积测量法在4例AD患者和5例对照者中检测灰质丢失的准确性，这些患者和对照者具有相似的基于VBM的海马测量值。使用统计参数映射（SPM99）进行VBM。
VBM的曲线下面积为0.96（95%可信区间，0.92 - 1.00），基于ROI的海马测量法的曲线下面积为0.89（95%可信区间，0.80 - 0.98），两者联合的曲线下面积为0.99（95%可信区间，0.96 - 1.00）。在具有相似基于ROI的海马测量值的受试者中，VBM在P < 0.0001时检测到AD患者存在萎缩；而在具有相似基于VBM的海马测量值的受试者中，体积测量法无显著差异（P = 0.11）。在逻辑回归模型中，两种测量方法均对鉴别有独立贡献（P = 0.004和P = 0.032）。
这些结果表明VBM更准确，但两种方法联合使用在检测AD患者海马萎缩方面具有最高的准确性。
