Lindqvist Daniel, Träskman-Bendz Lil, Vang Fredrik
Department of Clinical Sciences, Section of Psychiatry, Lund University Hospital, Sweden.
Arch Suicide Res. 2008;12(3):197-207. doi: 10.1080/13811110802100775.
The main purpose of the study was to investigate Hypothalamic-Pituitary-Adrenal (HPA) axis characteristics in relation to suicidal intent among suicide attempters with Major Depressive Disorder (MDD) and Adjustment Disorders (AD). The relationship between suicidal intent, assessed by means of the Suicidal Intent Scale (SIS), and serum cortisol after a Dexamethasone Suppression Test (DST) was investigated in 78 suicide attempters, divided into diagnostic subgroups. There was a significant negative correlation between suicidal intent and post DST cortisol in patients with MDD. Our findings may be attributed to pathophysiological processes, where a high suicidal intent is revealed during a potential chronic course of MDD, which in turn results in a seemingly normal stress system.
该研究的主要目的是调查重度抑郁症（MDD）和适应障碍（AD）自杀未遂者中下丘脑-垂体-肾上腺（HPA）轴特征与自杀意图的关系。通过自杀意图量表（SIS）评估的自杀意图与地塞米松抑制试验（DST）后的血清皮质醇之间的关系，在78名自杀未遂者中进行了调查，并将其分为诊断亚组。MDD患者的自杀意图与DST后皮质醇之间存在显著负相关。我们的发现可能归因于病理生理过程，即在MDD的潜在慢性病程中表现出较高的自杀意图，这反过来又导致应激系统看似正常。
