Billingsley Kelvin L, Buchwald Stephen L
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
J Org Chem. 2008 Jul 18;73(14):5589-91. doi: 10.1021/jo800727s. Epub 2008 Jun 25.
A highly efficient method for the palladium-catalyzed borylation of aryl halides with an inexpensive and atom-economical boron source, pinacol borane, has been developed. This system allows for the conversion of aryl and heteroaryl iodides, bromides, and several chlorides, containing a variety of functional groups, to the corresponding pinacol boronate esters. In addition to the increase in substrate scope, this is the first general method where relatively low quantities of catalyst and short reaction times can be employed.
已开发出一种高效方法,用于钯催化芳基卤化物与廉价且原子经济的硼源频哪醇硼烷进行硼化反应。该体系能将含有多种官能团的芳基和杂芳基碘化物、溴化物以及几种氯化物转化为相应的频哪醇硼酸酯。除了底物范围扩大外,这还是第一种可使用相对少量催化剂且反应时间短的通用方法。