一种通用的、实用的钯催化（杂）芳基氯化物和溴化物的氰化反应。
A general, practical palladium-catalyzed cyanation of (hetero)aryl chlorides and bromides.
机构信息
Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139 (USA).
出版信息
Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10035-9. doi: 10.1002/anie.201304188. Epub 2013 Aug 9.
Abstract
Playing it safe: The nontoxic cyanide source K4 [Fe(CN)6]·3H2O can be used for the cyanation of (hetero)aryl halides. The application of palladacycle catalysts prevents poisoning during catalyst formation, thereby allowing for low catalyst loadings, fast reaction times, and wide heterocyclic substrate scope.
摘要
稳妥之选
无毒氰源 K4[Fe(CN)6]·3H2O 可用于（杂）芳基卤化物的氰化反应。钯环催化剂的应用可防止催化剂形成过程中的中毒，从而可以使用低催化剂负载量、快速反应时间和广泛的杂环底物范围。
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