Jeong Yeon Jun, Lee Min Ro, Kim Jae Chun, Hwang Pyoung Han, Moon Woo Sung, Chung Myoung-Ja
Department of Surgery, Chonbuk National University Medical School, and Research Institute for Medical Science, Jeonju, Korea.
Pathol Int. 2008 Jul;58(7):445-50. doi: 10.1111/j.1440-1827.2008.02252.x.
Reported herein is an unusual case of carcinosarcoma of the colon. A 13-year-old girl was transferred to Chonbuk National University Hospital, Korea with a known pelvic mass. CT and magnetic resonance imaging confirmed a large pelvic mass. A sarcoma was diagnosed following colonoscopic biopsy. An ultra-low anterior resection with pelvic lymph node dissection was performed. The tumor consisted of a well-differentiated adenocarcinoma showing strong immunoreactivity to epithelial markers (pancytokeratin, cytokeratin 7, cytokeratin 19, cytokeratin 20, epithelial membrane antigen, and CEA) and a sarcomatous lesion with strong diffuse vimentin expression but no immunoreactivity to any of the six epithelial markers. Carcinosarcomas of the colon are extremely rare, and all reported cases involve adults. To the authors' knowledge, this is the first reported case of a carcinosarcoma of the colon in a child.
本文报道了一例罕见的结肠癌肉瘤病例。一名13岁女孩因已知盆腔肿块被转诊至韩国全北国立大学医院。CT和磁共振成像证实盆腔有一个大肿块。经结肠镜活检诊断为肉瘤。行低位前切除术并清扫盆腔淋巴结。肿瘤由对上皮标志物(全细胞角蛋白、细胞角蛋白7、细胞角蛋白19、细胞角蛋白20、上皮膜抗原和癌胚抗原)呈强免疫反应性的高分化腺癌和弥漫性波形蛋白强表达但对六种上皮标志物均无免疫反应性的肉瘤样病变组成。结肠癌肉瘤极为罕见,所有报道病例均为成人。据作者所知,这是首例儿童结肠癌肉瘤报道病例。