Kukan M, Koprda V, Bezek S, Kálal J, Labský J, Trnovec T
Institute of Experimental Pharmacology, Slowak Academy of Sciences, Bratislava.
Pharmazie. 1991 Jan;46(1):37-9.
The fate of lyophilized (methylmethacrylate-14C, 2-hydroxyethylmethacrylate, butylacrylate) nanoparticles was studied in male Wistar rats after p.o. administration. It was found that at least 4% of the dose of 14C was absorbed from the gastrointestinal tract after a single dose with these nanoparticles. Some radioactivity (less than 0.15% of dose) was found 7 d after administration in lung, spleen and liver. As expected excretion of the label was predominated via the feces. Ten d of p.o. treatment of rats with lyophilized nanoparticles (1 g/kg of body weight) was shown to prolong significantly zoxazolamine paralysis time. This result suggests that lyophilized nanoparticles decreased elimination of zoxazolamine.
研究了冻干的（甲基丙烯酸甲酯 - 14C、甲基丙烯酸2 - 羟乙酯、丙烯酸丁酯）纳米颗粒经口给药后在雄性Wistar大鼠体内的命运。结果发现，单次给予这些纳米颗粒后，至少4%的14C剂量从胃肠道被吸收。给药7天后，在肺、脾和肝脏中发现了一些放射性（小于剂量的0.15%）。正如预期的那样，标记物的排泄主要通过粪便。用冻干纳米颗粒（1 g/kg体重）对大鼠进行10天的经口治疗显示，可显著延长唑沙宗麻痹时间。这一结果表明，冻干纳米颗粒减少了唑沙宗的消除。
