Sapota A
Department of Metabolism of Toxic Substances, Institute of Occupational Medicine, Lodz, Poland.
Pol J Occup Med Environ Health. 1991;4(1):55-66.
The disposition of butyl-(2,3-14C)-acrylate has been studied following intraperitoneal and oral administration to rats. Most of the administrated acrylate underwent rapid metabolism and excretion with expired air (more than 70% of the dose) and urine (15-22%). Most of 14C found in tissues was associated with the liver and kidneys. The level of 14C associated with most of the examined tissues remained unchanged, at least, for the first 8-10 hours, followed by its fairly rapid loss. The only exception was erythrocytes, fat and the sciatic nerve. Significant differences in the rate of 14C loss from tissues were found in relation to the route of its administration.
研究了丁基 -（2,3 - ¹⁴C）- 丙烯酸酯经腹腔注射和口服给予大鼠后的处置情况。大部分给予的丙烯酸酯迅速代谢并通过呼出气体（超过剂量的70%）和尿液（15 - 22%）排出。在组织中发现的大部分¹⁴C与肝脏和肾脏有关。与大多数检查组织相关的¹⁴C水平至少在最初的8 - 10小时内保持不变，随后相当迅速地下降。唯一的例外是红细胞、脂肪和坐骨神经。在组织中¹⁴C损失率方面发现了与给药途径相关的显著差异。
