Kukan M, Bezek S, Koprda V, Labský J, Kálal J, Bauerová K, Trnovec T
Institute of Experimental Pharmacology, Centre of Physiological Sciences, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
Pharmazie. 1989 May;44(5):339-40.
The fate of 14C-terpolymer (methylmethacrylate-14C, 2-hydroxyethylmethacrylate, butylacrylate) nanoparticles was studied in male Wistar rats after peroral administration. These nanoparticles may reach systemic circulation as evidenced by the plasma 14C level, excretion of the label in the urine, as well as organ label deposition. It was found that at least 2% of the dose of 14C was absorbed from the gastrointestinal tract. As expected, the radioactive nanoparticles were excreted predominantly via the feces. The amount of the label in the gastrointestinal tract, liver, and carcasses fell below the limit of detection on day seven after administration. However in the spleen and lung some slight radioactivity persisted after 7 d of experiment.
研究了经口给药后14C三元共聚物（甲基丙烯酸甲酯-14C、甲基丙烯酸2-羟乙酯、丙烯酸丁酯）纳米颗粒在雄性Wistar大鼠体内的命运。血浆14C水平、尿液中标记物的排泄以及器官标记物沉积均表明这些纳米颗粒可能进入体循环。研究发现，至少2%的14C剂量从胃肠道吸收。正如预期的那样，放射性纳米颗粒主要通过粪便排出。给药后第7天，胃肠道、肝脏和尸体中的标记物含量降至检测限以下。然而，在实验7天后，脾脏和肺部仍有一些轻微的放射性。
