Stozek T, Borysiewicz J
Lehrstuhl für Pharmazeutische Technologie und Biopharmazie, Medizinischen Akademie Kraków, Polen.
Pharmazie. 1991 Jan;46(1):39-41.
Liposomes containing griseofulvin have been prepared by shaking method. Lecithin and cholesterol were used to compose phospholipid bilayer of liposomes. The suspension of liposomes in 0.9% sodium chloride and the suspension of griseofulvin in 0.25% iostonic methylcellulose solution were used in the comparative study in vivo. Both suspensions were administered intragastricly to rats. Parameters of bioavailability have been found on the basis of the changes in griseofulvin plasma concentrations versus time. Intragastric administration of griseofulvin in liposomes suspension demonstrates ca. 40% higher Cmax and AUC when compared to these of griseofulvin suspension which indicates a better bioavailability.
采用振荡法制备了含有灰黄霉素的脂质体。卵磷脂和胆固醇用于构成脂质体的磷脂双层。在体内比较研究中使用了脂质体在0.9%氯化钠中的悬浮液和灰黄霉素在0.25%等渗甲基纤维素溶液中的悬浮液。两种悬浮液均经胃内给予大鼠。根据灰黄霉素血浆浓度随时间的变化确定了生物利用度参数。与灰黄霉素悬浮液相比，胃内给予脂质体悬浮液中的灰黄霉素时，其Cmax和AUC约高40%，这表明生物利用度更好。
