Stozek T, Krówczyński L
Pharmazie. 1986 Sep;41(9):645-7.
Liposomes containing dipyridamole have been prepared by evaporating-shaking method. Phospholipid bilayer consisted of lecithin and cholesterol in three varying molar rations: 5:2, 7:2, 10:2. According to lipid layer composition the obtained liposomes varied in size and amount of dipyridamole entrapped. The suspension of liposomes in 0.9% sodium chloride prepared with lecithin and cholesterol in molar ratio 7:2 was chosen to the study in vivo. A suspension of dipyridamole in 0.9% sodium chloride was used comparatively. Particle size of dipyridamole was similar to that of liposomes with entrapped substance. Both suspensions were administrated to guinea pigs orally or intraperitoneally. The study has shown that liposomally-entrapped dipyridamole has essential and advantageous effect on its absorption after oral or intraperitoneal administration when compared with dipyridamole itself. The best bioavailability has been demonstrated by the suspension of liposomes after intraperitoneal administration.
采用蒸发-振荡法制备了含有双嘧达莫的脂质体。磷脂双层由卵磷脂和胆固醇按三种不同摩尔比组成：5:2、7:2、10:2。根据脂质层组成，所获得的脂质体在大小和包封的双嘧达莫量上有所不同。选择用摩尔比为7:2的卵磷脂和胆固醇在0.9%氯化钠中制备的脂质体悬浮液进行体内研究。相对地，使用了双嘧达莫在0.9%氯化钠中的悬浮液。双嘧达莫的粒径与包封有物质的脂质体相似。两种悬浮液均经口或腹腔注射给予豚鼠。研究表明，与双嘧达莫本身相比，脂质体包封的双嘧达莫在口服或腹腔注射后对其吸收具有重要且有利的作用。腹腔注射后脂质体悬浮液表现出最佳的生物利用度。
