Burdick Katherine E, Robinson Delbert G, Malhotra Anil K, Szeszko Philip R
Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA.
J Int Neuropsychol Soc. 2008 Jul;14(4):640-5. doi: 10.1017/S1355617708080727.
Although neurocognitive deficits have been identified in obsessive-compulsive disorder (OCD), little research has focused on whether these deficits are generalized or specific to a given cognitive domain. We assessed the relative strengths and weaknesses of 26 adult patients with OCD compared to 38 age- and sex-matched healthy volunteers in domains of motor, verbal memory, visual memory, reasoning/problem solving, processing speed processing, and language. Profile analysis revealed an overall neurocognitive deficit of 1/2 standard deviation in OCD patients versus healthy volunteers, with relative weaknesses in motor and processing speed domains. In contrast, relative strengths were observed in language, verbal memory, and reasoning/problem solving. Our findings demonstrate neurocognitive impairment in OCD that may relate to functional outcome in this population. Findings of specific abnormalities on tasks of motor and processing speed are consistent with a hypothesized role of thalamocortical and basal ganglia regions in the pathogenesis of OCD.
尽管在强迫症（OCD）中已发现神经认知缺陷，但很少有研究关注这些缺陷是普遍存在的还是特定于某个认知领域。我们评估了26名成年强迫症患者与38名年龄和性别匹配的健康志愿者在运动、言语记忆、视觉记忆、推理/问题解决、处理速度以及语言等领域的相对优势和劣势。轮廓分析显示，与健康志愿者相比，强迫症患者总体神经认知缺陷为1/2个标准差，在运动和处理速度领域相对较弱。相比之下，在语言、言语记忆和推理/问题解决方面观察到相对优势。我们的研究结果表明强迫症存在神经认知损害，这可能与该人群的功能结局有关。运动和处理速度任务上的特定异常结果与丘脑皮质和基底神经节区域在强迫症发病机制中的假设作用一致。
