Kertzman Semion G, Poyurovski Michael, Faragian Sarit, Weizman Ronit, Cohen Koby, Aizer Anat, Weizman Abraham, Dannon Pinhas N
Psychiatry Division, Beer-Yaakov-Ness Ziona Mental Health Center, Tel Aviv, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Front Psychiatry. 2018 Dec 4;9:652. doi: 10.3389/fpsyt.2018.00652. eCollection 2018.
Obsessive-compulsive disorder (OCD) and pathological gambling (PG) are common disorders. The cognitive models of OCD and PG focus on abnormalities in response inhibition. Although, these functions have been studied in different PG and OCD samples, no study has compared the response inhibition in both. Medication-naïve OCD ( = 61) and PG subjects ( = 109) and healthy controls ( = 131) performed CPT and Go/NoGo tasks. Compared to healthy controls (HC), PG and OCD groups underperformed on speed and exhibited larger time variability on the CPT and Go/NoGo task. Only in OCD patients, a positive correlation between omission errors and response time (RT) was observed in the CPT. At the Go/NoGo task, a negative correlation between false alarms and RT (a fast-errors trade-off) was significant only in the PG group. The HC group had greater sensitivity values (d') than the OCD and PG groups in the Go/NoGo task. The PG group displayed lower d' values and more conservative response criterion in the CPT. In addition, only the OCD group expressed a high switching cost compared to both the PG and HC groups in terms of the RT and d' values. Both the PG and OCD groups demonstrated impaired response inhibition compared to the HC group. On several measures, the OCD and PG groups showed comparable impairments, and in others these were distinct. Thus, it appears that distinct neurocognitive patterns are involved in performance of the CPT and the Go/NoGo tasks among OCD and PG subjects whose cognitive status is currently under intensive investigation.
强迫症（OCD）和病理性赌博（PG）是常见的疾病。强迫症和病理性赌博的认知模型关注反应抑制的异常。尽管已经在不同的病理性赌博和强迫症样本中对这些功能进行了研究，但尚无研究对两者的反应抑制进行比较。未接受过药物治疗的强迫症患者（n = 61）、病理性赌博患者（n = 109）和健康对照者（n = 131）进行了连续性能测试（CPT）和Go/NoGo任务。与健康对照者（HC）相比，病理性赌博和强迫症组在速度方面表现较差，并且在CPT和Go/NoGo任务中表现出更大的时间变异性。仅在强迫症患者中，在CPT中观察到遗漏错误与反应时间（RT）之间存在正相关。在Go/NoGo任务中，虚报与RT之间的负相关（快速错误权衡）仅在病理性赌博组中显著。在Go/NoGo任务中，健康对照组的敏感性值（d'）高于强迫症和病理性赌博组。病理性赌博组在CPT中显示出较低的d'值和更保守的反应标准。此外，仅强迫症组在RT和d'值方面与病理性赌博组和健康对照组相比表现出较高的转换成本。与健康对照组相比，病理性赌博和强迫症组均表现出反应抑制受损。在几项测量中，强迫症和病理性赌博组表现出相当的损伤，而在其他测量中则有所不同。因此，在强迫症和病理性赌博受试者中，CPT和Go/NoGo任务的表现似乎涉及不同的神经认知模式，其认知状态目前正在深入研究中。
