van den Beukel Tessa O, Dekker Friedo W, Siegert Carl E H
Department of Nephrology, Sint Lucas Andreas Hospital, Amsterdam, The Netherlands.
Nephrol Dial Transplant. 2008 Nov;23(11):3571-7. doi: 10.1093/ndt/gfn336. Epub 2008 Jun 24.
Data from the United States and Canada suggest that survival rates of Caucasian dialysis patients are lower compared to those of black patients and patients from Asian regions. Information regarding the survival rate of immigrant dialysis patients in Europe is scarce.
We retrospectively analysed incident haemodialysis (HD) and peritoneal dialysis (PD) patients who entered an Amsterdam renal service between January 1996 and December 2005. To explore the origin of differences in survival between natives and immigrants, we ran a series of Cox models with adjustment for demographic, clinical and laboratory variables at baseline and initial adequacy variables.
Of 303 incident dialysis patients, 58% were natives and 42% were immigrants. Fifty-nine percent of natives and 54% of immigrants had HD as initial treatment modality. At initiation of dialysis, native patients were older and had higher rates of vascular and coronary artery diseases and malignancies and a lower prevalence of hypertension. Glomerulonephritis was more common among immigrants as primary kidney disease. Mean haematocrit and calcium levels for natives were higher compared to immigrants. Cox proportional hazards analysis revealed an increased relative mortality risk (RR) of 2.7 [95% confidence interval (CI) 1.9-3.9] for natives compared to immigrants. Adjustment for age at the start of dialysis attenuated the RR to 1.9 (CI 1.3-2.7). Adjustment for the other variables did not materially influence this RR.
We demonstrate increased survival for immigrant compared to native dialysis patients in an urban setting in the Netherlands. This survival advantage is only partly explained by younger age of immigrants at the start of dialysis compared to native patients.
来自美国和加拿大的数据表明,与黑人患者及亚洲地区患者相比,白种人透析患者的生存率较低。欧洲关于移民透析患者生存率的信息匮乏。
我们回顾性分析了1996年1月至2005年12月期间进入阿姆斯特丹肾脏服务机构的新发血液透析(HD)和腹膜透析(PD)患者。为探究本地人与移民在生存方面差异的根源,我们运行了一系列Cox模型,并对基线时的人口统计学、临床和实验室变量以及初始充分性变量进行了调整。
在303例新发透析患者中,58%为本地人,42%为移民。59%的本地人及54%的移民将HD作为初始治疗方式。开始透析时,本地患者年龄较大,血管和冠状动脉疾病及恶性肿瘤的发生率较高,高血压患病率较低。肾小球肾炎在移民中作为原发性肾脏疾病更为常见。本地人的平均血细胞比容和钙水平高于移民。Cox比例风险分析显示,与移民相比,本地人的相对死亡风险(RR)增加了2.7[95%置信区间(CI)1.9 - 3.9]。对透析开始时的年龄进行调整后,RR降至1.9(CI 1.3 - 2.7)。对其他变量进行调整并未对该RR产生实质性影响。
我们证明,在荷兰城市环境中,移民透析患者的生存率高于本地透析患者。这种生存优势仅部分归因于与本地患者相比,移民在透析开始时年龄较小。