Govorin N V, Zlova T P, Akhmetova V V, Tarasova O A
Zh Nevrol Psikhiatr Im S S Korsakova. 2008;108(5):51-5.
The treatment with cerebrolysin combined with psychological correction was conducted in 24 children, aged 4-6 years, with mental developmental delay. The effect of this drug was compared to placebo (20 patients with mental development delay) and control groups (35 healthy children). After cerebrolysin therapy effect of cerebrolysin (0,1 mg/1kg of body mass during 42 day) was assessed using neuropsychological data and a set of different pathophysiological indices which reflected the biochemical, immunological and neurophysiological status of patients. After cerebrolysin therapy significant improvement of the mental state, including preconditions of intellect, and motor functions specific for mental development delay was found. These changes were correlated with the positive dynamics of some indices - lipid peroxidation, immune status, hormonal shifts and parameters of neurodegeneration-neuroprotection processes.
对24名4至6岁智力发育迟缓儿童进行了脑蛋白水解物联合心理矫正治疗。将该药物的效果与安慰剂组（20名智力发育迟缓患者）和对照组（35名健康儿童）进行了比较。在脑蛋白水解物治疗后（42天内按0.1mg/1kg体重给药），使用神经心理学数据和一组反映患者生化、免疫和神经生理状态的不同病理生理指标对脑蛋白水解物的疗效进行了评估。脑蛋白水解物治疗后，发现精神状态有显著改善，包括智力前提条件以及智力发育迟缓特有的运动功能。这些变化与一些指标的积极动态相关——脂质过氧化、免疫状态、激素变化以及神经变性-神经保护过程的参数。
